Posts by tag
cachexia
Targeting a circulating cytokine offers new hope in cancer cachexia
Among patients with cancer cachexia and elevated levels of the cytokine GDF-15, inhibiting GDF-15 with ponsegromab resulted in increased weight gain. The study, published in the New England Journal of Medicine, 14 September, showed that in comparison to placebo, patients taking ponsegromab…
Genetic targets identified for cancer-associated cachexia
Distinct patterns of genes have been shown to be active in the tumours of non-small-cell lung cancer patients who go on to develop cachexia, including high activity of the protein GDF15. The study, published in Nature Medicine, April 2023 issue,…
New target identified for preventing cachexia
Targeting a specific enzyme in muscle could help cancer patients avoid the muscle wasting condition cachexia. The study, published in PNAS (October 17), found that a previously overlooked enzyme, known as UBR2, plays a critical role in cancer patients developing…
Study shines new light on breast cancer’s sweet tooth
Breast cancer cells impair the function of pancreatic islets to make them produce less insulin than required, resulting in higher blood glucose levels in breast cancer patients compared to women without cancer. The study, published in Nature Cell Biology (30th…
Dietary counseling remains cornerstone of cachexia management, say new ASCO guidelines
For cancer cachexia, dietary counseling should be offered with the goal of providing patients and caregivers with management advice, conclude the first guidelines on cachexia ever published by the American Society of Clinical Oncology (ASCO). In the absence of evidence,…