Biology basic
Ethnic differences in cancer biology: What we are learning, and why it matters
There have been great strides in our understanding of cancer genomics – the mutational events that lead to high cancer risks and those that drive progression in cancer patients. Using…
Angiogenesis: how cutting the blood supply became a tool against cancer
The human body is permeated by an extensive network of approximately sixty thousand miles of blood vessels – an intricately organised system designed for the precise and efficient distribution of…
Ultra-high dose rate radiation: is FLASH the future?
Radiation that kills only tumour cells and spares healthy tissue? It sounds too good to be true. But if the promise of recent research is fulfilled, the FLASH technique of…
Cracking RAS: It took over 30 years to hit this ubiquitous oncogene – was it worth the wait?
RAS oncogenes and their proteins have central roles in almost all cancers, including leukaemias, multiple myelomas, skin cancers and many solid tumours, making the RAS protein family an ideal cancer…
The CRISPR revolution: it’s transforming cancer research, can it do the same for treatment?
CRISPR is a revolutionary gene-editing tool that allows scientists to cut DNA with extraordinary precision and make changes to the genome. The technology was a gift to cancer researchers, whose…
A blood test for early detection of any cancer: What’s the ideal? Are we getting there?
Earlier cancer diagnosis could make a huge difference to cancer survival rates – only two in ten of those diagnosed after their cancer has metastasised survive, compared with nine in…
Nanotechnology is steadily expanding its many roles in tackling cancer
A nanomedicine, as defined by the US National Institutes of Health, is a “highly specific medical intervention at the molecular scale for curing disease or repairing damaged tissues… ” For…
Cancer and the immune system: turning insights into treatments
The vision of harnessing our immune systems to fight cancer has been tantalising scientists and doctors for more than a century. The idea had a strong scientific rationale: over millions…
How organoids could help match treatments to tumours
When diagnosed with cancer, few things are more important than having confidence that the treatment you are prescribed is the best possible option for you. For many cancers, particularly the…
What can we expect from mRNA cancer vaccines?
Messenger RNA vaccines turned around Europe’s fight against the Covid pandemic. Less than a year after the first lockdowns were declared, mRNA vaccines got regulatory approval for emergency use, first…