Posts by tag
immune checkpoint blockade (ICB)
Harmful bacteria play greater role in predicting outcomes of immune checkpoint blockade in melanoma
Harmful gut bacteria may play a greater role than beneficial bacteria in determining efficacy of immune checkpoint blockade in melanoma patients. The study, published in Nature Medicine (28 February), found microbial signatures containing Lachnospiraceae species were connected to favourable anti-programmed…
Immunotherapy toxicities demand a joined up approach from oncologists and organ specialists
Adverse effects of cancer therapies have long been at the root of decision making for interventions in all modalities – surgery, radiotherapy and medical – and especially in the latter category of anti-cancer drugs. Most people have heard of some…
Preclinical model identifies predictors of checkpoint inhibitor response
A study published in PNAS (Chen IX, et al. PNAS 2020) of a new mouse model has enabled the identification of distinct gene signatures that distinguish responders from non-responders to immune checkpoint blockade (ICB). “Our findings provide a general approach…