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Cancerworld Magazine > immune checkpoint blockade (ICB)

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immune checkpoint blockade (ICB)

3 posts
Harmful bacteria play greater role in predicting outcomes of immune checkpoint blockade in melanoma
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Harmful bacteria play greater role in predicting outcomes of immune checkpoint blockade in melanoma

  • Janet Fricker
  • 4 March 2022

Harmful gut bacteria may play a greater role than beneficial bacteria in determining efficacy of immune checkpoint blockade in melanoma patients. The study, published in Nature Medicine (28 February), found microbial signatures containing Lachnospiraceae species were connected to favourable anti-programmed…

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Immunotherapy toxicities demand a joined up approach from oncologists and organ specialists
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Immunotherapy toxicities demand a joined up approach from oncologists and organ specialists

  • Marc Beishon
  • 24 February 2021

Adverse effects of cancer therapies have long been at the root of decision making for interventions in all modalities – surgery, radiotherapy and medical – and especially in the latter category of anti-cancer drugs. Most people have heard of some…

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Preclinical model identifies predictors of checkpoint inhibitor response
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Preclinical model identifies predictors of checkpoint inhibitor response

  • Janet Fricker
  • 22 September 2020

A study published in PNAS (Chen IX, et al. PNAS 2020) of a new mouse model has enabled the identification of distinct gene signatures that distinguish responders from non-responders to immune checkpoint blockade (ICB). “Our findings provide a general approach…

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