Posts by tag
chemotherapy
Strategies Needed to Prioritise Screening in Survivors of Childhood Cancer
Survivors of childhood cancer experience accelerated onset of ageing-related diseases, regardless of prior radiation exposure. The simulation modelling study, published in JAMA Oncology, online March 20, found that chronic health conditions developed 10 to 20 years earlier than expected and…
Breast cancer treatments may accelerate ageing
Breast cancer treatments activate genes associated with biological ageing. The study, published in the Journal of the National Cancer Institute, 8 October, suggests that chemotherapy, radiation, and surgery all lead to statistically significant increases in cellular senescence and DNA damage…
Common blood pressure drug could be used in AML to cut cardiotoxicity and improve response to chemotherapy
Treating acute myeloid leukaemia with losartan, a commonly used blood pressure agent, achieved the dual benefits of enhancing chemotherapy efficacy and preventing cardiotoxicity in a mouse model. The study, published in Science Translational Medicine, 19 June, demonstrated both benefits were…
Older adults with advanced cancers may do better on modified regimens
Lowering the dose and adjusting the schedule may help older adults with advanced cancer better tolerate chemotherapy. The cohort study, published in JAMA Network Open, February 15, found older patients with advanced cancer who underwent primary treatment modification had a…
Quality care, free of charge, and closer to home: expanding access to cancer services in India
Rahul Jain and his mother Shashi were in Pune – 1,000 km from their home in Ashoknagar, in the neighbouring state of Madhya Pradesh – when they were told there was no hope. They had undertaken the long journey together…
Chemobrain: it’s real, it’s troublesome and it deserves more attention
Fiona Henderson was part way through her psychology degree when she received her breast cancer diagnosis. Right after treatments finished, she returned to her studies – initially without a problem. “Three or four months later, I really struggled. I was…
Study suggests prehabilitation should become standard of care in oesophageal cancer
Enrolling oesophageal cancer patients in prehabilitation exercise programmes can boost tumour regression during chemotherapy. The small study, published in British Journal of Sports Medicine (online 1 February, 2022), demonstrated improved pathological, radiological and immunological responses to chemotherapy for those in the…
Drugs shortages: ‘We parents of children with cancer are too exhausted to protest’
When it all started, Ioana Oprea did not have a spare moment to come to terms with what had happened ‒ to truly take in the fact that her son Teodor had a brain tumour. In the autumn of 2020,…
Immunotherapy plus chemo: benefits in lung cancer neoadjuvant treatment
Adding a check point inhibitor to chemotherapy as neoadjuvant treatment for resectable non-small cell lung cancer (NSCLC) produced significant improvements of pathological complete response (pCR) in comparison to chemotherapy alone. The CheckMate-816 study, presented at the American Association for Cancer…
Right drug, wrong patient: here’s how we improve our targeting
When it comes to precision and personalised medicine (PPM), clinical practice in oncology takes pride in developing and administering treatments that selectively target components of tumour cells. But, PPM is a model that also takes into account the inherent variability…