Posts by tag
liquid biopsy
Safely pausing or stopping treatment: could this be the future for solid tumours?
The success of treatment cessation in chronic myeloid leukaemia (CML), outlined in an earlier Cancerworld feature, is opening the way for treatment breaks – or cessation with monitoring – to be considered in advanced solid tumours, including breast, kidney, colorectal,…
Ultra-sensitive immunoassay detects key protein produced by cancer cells
A blood test detecting a key protein produced by cancer cells is showing promise as an early indicator of cancer. The study, published in Cancer Discovery, September 12, suggests that the ultra-sensitive assay for LINE-1-ORF1p offers potential as an effective…
Multi-cancer early detection blood test speeds up cancer diagnosis
A multi-cancer early detection test showed a positive predictive accuracy of 75% and negative predictive accuracy of 98% in a population referred for diagnostic follow-up after presenting to primary care with symptoms of cancer. The SYMPLIFY study, abstract 1501, presented…
Circulating tumour DNA provides early warning of metastatic breast cancer
In high-risk hormone receptor positive breast cancer circulating tumour DNA (ctDNA) was identified a median of one year before distant metastasis. The study, published in the Journal of Clinical Oncology (4th June, 2022), represents the first prospective investigation of plasma…
Molecular diagnostics and NGS in the clinic: where are we and where do we need to go?
The development of next generation sequencing (NGS) has been a game changer for our understanding of genetics, and in turn for many aspects of biomedicine. This includes cancer, where it has led to greater understanding of the genetic changes that…