Posts by tag
CDK4/6 inhibitors
2 posts
Mechanisms linking chronic stress to raised metastasis risk discovered
Stress causes neutrophils to form sticky ‘web-like structures’, making body tissues more susceptible to cancer metastasis. The study published in Cancer Cell, 22 February, demonstrated that the stress hormone glucocorticoid leads to the formation of neutrophil extracellular traps (NETs), known…
Adding a CDK4/6 inhibitor to endocrine therapy improves outcomes in HR+ HER2– early-stage breast cancer
Adding the CDK4/6 inhibitor ribociclib to standard-of-care adjuvant endocrine therapy for treatment of hormone receptor-positive HER2-negative early-stage breast cancer reduced risk of recurrence by 25%. The phase III NATALEE study, abstract LBA500, presented at the ASCO 2023 Annual Meeting, held…