Posts by tag
chronic lymphocytic leukaemia
2 posts
Second-generation BTK inhibitor shows promise as fixed-duration therapy in CLL
Treatment with the second-generation Bruton tyrosine kinase (BTK) inhibitor acalabrutinib plus the BCL2 inhibitor venetoclax (with or without the CD20 inhibitor obinutuzumab), delivered as fixed-duration therapies, significantly improved progression free survival in comparison with standard-of-care chemotherapy in previously untreated patients…
Transcriptional signature provides clue to CAR T cell longevity
A transcriptional signature of 21 genes has been found to occur across patients with paediatric B-cell acute lymphoblastic leukaemia who have durable responses and long-lived CAR T cells. The UK study, published online in Nature Medicine, July 6, did not…