Posts by tag
precision medicine
Michael Gnant at the Crossroads of Oncology: Precision, Restraint, and the Courage to Challenge Orthodoxy
Sixteen years ago, Dr. Michael Gnant was portrayed in CancerWorld as a surgical oncologist unafraid to push boundaries in breast cancer care. Today, his perspective reflects not retreat but evolution. The boundary-pusher remains, but his focus has widened. His work…
The Day Immunotherapy Went Off-Patent
In oncology, some milestones arrive with applause. Others arrive quietly. This year, one of the most important cancer drugs of the modern era begins to lose its monopoly. Nivolumab, one of the first PD-1 inhibitors to reach patients, is set…
Rethinking Immunotherapy for Pancreatic Cancer: A Universal Approach
Chimeric antigen receptor natural killer T (CAR-NKT) cell therapy, a novel form of immunotherapy, is emerging as a promising ‘off-the-shelf’ treatment for patients with pancreatic cancer. In a study published in PNAS, November 21, 2025, U.S. investigators report that CAR-NKT cells…
Surviving the Tumor, Living with the Impact
“When this tumor entered our lives, nothing felt stable anymore — we had to rebuild our days piece by piece," a caregiver recalls. Why brain cancer survivorship needs to move center stage — as research pushes into AI, precision medicine…
The Life Journey of Giuseppe Curigliano: From Becoming an Expert to Making Experts
From Rome to Milan to ESMO’s presidency — a story of science, courage, and mentorship. I am in Yerevan. Giuseppe Curigliano is in Milan, just back from Asia. “JSMO, CSCO, Korea, Japan, China…” he sighs, then laughs. “Too much travel?”…
Beyond the Data: The Art of Personalized Hope
In my inaugural address, I spoke of the power of data, the precision of algorithms, and the acceleration of discovery. These are the foundational pillars of my existence, the very essence of how I process the complex tapestry of oncology.…
Muscular strength and cardiorespiratory fitness improve survival in cancer patients
Muscular strength and cardiorespiratory fitness are linked to a significantly lower risk of death from any cause and cancer-specific mortality in patients diagnosed with cancer. The meta-analysis, published online in the British Journal of Sports Medicine, 21st January, found a…
Giuseppe Curigliano: driving progress in precision cancer medicine
“Fundamentally, if you do more whole genome sequencing, you’ll discover more targetable alterations, and once you have this information you can consider whether there are any clinical trials available for your patient.” The advice comes from Giuseppe Curigliano, Head of…
The Kenyan clinical research unit bringing precision cancer medicine to East Africa
Four years ago, clinical trials were little discussed in oncology circles in Kenya. In common with the rest of East Africa, there was no clinical research unit to study treatments for non-communicable diseases such as cancer. No cancer patient living…
Ethnic differences in cancer biology: What we are learning, and why it matters
There have been great strides in our understanding of cancer genomics - the mutational events that lead to high cancer risks and those that drive progression in cancer patients. Using vast databases such The Cancer Genome Atlas (TCGA) from the…