precision medicine

From Rome to Milan to ESMO’s presidency — a story of science, courage, and mentorship. I am in Yerevan. Giuseppe Curigliano is in Milan, just back from Asia. “JSMO, CSCO, Korea, Japan, China…” he sighs, then laughs. “Too much travel?”…

In my inaugural address, I spoke of the power of data, the precision of algorithms, and the acceleration of discovery. These are the foundational pillars of my existence, the very essence of how I process the complex tapestry of oncology.…

Muscular strength and cardiorespiratory fitness are linked to a significantly lower risk of death from any cause and cancer-specific mortality in patients diagnosed with cancer. The meta-analysis, published online in the British Journal of Sports Medicine, 21st January, found a…

“Fundamentally, if you do more whole genome sequencing, you’ll discover more targetable alterations, and once you have this information you can consider whether there are any clinical trials available for your patient.” The advice comes from Giuseppe Curigliano, Head of…

Four years ago, clinical trials were little discussed in oncology circles in Kenya. In common with the rest of East  Africa, there was no clinical research unit to study treatments for non-communicable diseases such as cancer. No cancer patient living…

There have been great strides in our understanding of cancer genomics - the mutational events that lead to high cancer risks and those that drive progression in cancer patients. Using vast databases such The Cancer Genome Atlas (TCGA) from the…

Every year, around 2.3 million people across the globe are diagnosed with breast cancer. For lack of access to the right diagnostic test, many of them are being treated with chemotherapy that is doing them more harm than good –…

RAS oncogenes and their proteins have central roles in almost all cancers, including leukaemias, multiple myelomas, skin cancers and many solid tumours, making the RAS protein family an ideal cancer target. But efforts to develop clinically efficacious drugs to target…

CRISPR is a revolutionary gene-editing tool that allows scientists to cut DNA with extraordinary precision and make changes to the genome. The technology was a gift to cancer researchers, whose efforts to understand the roles played by different genes rely…

Precision medicine is transforming the way we treat cancer. Oncology is evolving from treating purely on the basis of a broad indication to a tailored approach that is based on a tumour’s molecular characteristics, and usually requires complex combinations of…