Cancerworld Magazine
  • About the Magazine
    • Editorial Team
    • Leadership and Management
    • Events
    • Magazine
    • Archive
    • Contacts
  • Articles
    • Policy
    • Practice Points
    • Delivery of Care
    • Biology basic
    • Medicine
    • Featured
  • Contents
    • News
    • Editorials
    • Interviews to the Expert
    • In the Hot Seat
    • Profiles
    • Obituaries
    • Voices
    • Partnership
    • Supported contents
  • Media Corner
    • Journalist Cancer Guide
    • Cancer Journalism Award
    • Cancer Journalist Grant
SUBSCRIBE FOR FREE
Facebook
Twitter
LinkedIn
Cancerworld Magazine
Cancerworld Magazine
  • About the Magazine
    • Editorial Team
    • Leadership and Management
    • Events
    • Magazine
    • Archive
    • Contacts
  • Articles
    • Policy
    • Practice Points
    • Delivery of Care
    • Biology basic
    • Medicine
    • Featured
  • Contents
    • News
    • Editorials
    • Interviews to the Expert
    • In the Hot Seat
    • Profiles
    • Obituaries
    • Voices
    • Partnership
    • Supported contents
  • Media Corner
    • Journalist Cancer Guide
    • Cancer Journalism Award
    • Cancer Journalist Grant
Cancerworld Magazine > News > Metastatic prostate cancer: cabazitaxel shows quality of life benefits over both abiraterone and enzalutamide
  • News

Metastatic prostate cancer: cabazitaxel shows quality of life benefits over both abiraterone and enzalutamide

  • 6 October 2020
  • Janet Fricker
Metastatic prostate cancer: cabazitaxel shows quality of life benefits over both abiraterone and enzalutamide
Total
0
Shares
0
0
0
0
0

In addition to previously reported survival benefits, the taxane cabazitaxel improved quality of life in patients with advanced metastatic prostate cancer compared to the androgen signalling targeted inhibitors abiraterone and enzalutamide, reports the latest analysis of the CARD trial (Fizazi K et al. Lancet Oncol 2020).

“This analysis can provide reassurance to physicians and patients that receiving cabazitaxel chemotherapy will not negatively affect HRQOL (health related quality of life) or induce additional toxicity when compared with oral androgen signalling-targeted inhibitors,” write the authors of the European study.

For the open-label phase IV CARD study, between November 2017 and November 2018, 255 patients with confirmed metastatic castration-resistant prostate cancer who had previously received docetaxel plus an androgen-signalling-targeted inhibitor (abiraterone or enzalutamide) were randomly assigned 1:1 to receive cabazitaxel (n=129) or to the alternative androgen-signalling-targeted inhibitor, i.e. from abiraterone to enzalutamide or vice versa (n= 126). CARD involved 62 clinical sites across 13 European countries.

Outcomes regarding disease progression and survival were reported at the end of 2019 in the New England Journal of Medicine. After a median follow-up of 9.2 months, 73.6% of patients in the cabazitaxel group had experienced disease progression (evaluated by imaging) or death compared to 80.2% in the group receiving abiraterone or enzalutamide (HR=0.54; 95%CI 0.40‒0.73; P<0.001).

Many patients with advanced metastatic castration-resistant prostate cancer have bone metastases, which cause pain and deterioration of quality of life. As prognosis for metastatic prostate cancer has improved, quality of life is increasingly important, yet it continues to be underevaluated. The current analysis by Karim Fizazi, the corresponding author from Institut Gustave Roussy, France, and colleagues, set out to explore the effects on quality of life.

The results showed:

  • Pain response (defined as at least a 30% decrease from baseline in average BPI-SF pain intensity scores) was observed in 46% of patients with cabazitaxel versus 19% with abiraterone or enzalutamide (P<0.0001).
  • Median time to pain progression was not estimable with cabazitaxel and was 8.5 months with abiraterone or enzalutamide (HR=0.55, 95%CI 0.32-0.97; log-rank P=0.035).
  • Median time to symptomatic skeletal events (defined as either the use of external beam radiotherapy to relieve bone pain, occurrence of new symptomatic pathological fractures, occurrence of spinal compression, or tumour-related orthopaedic surgical intervention) was not estimable with cabazitaxel, and was 16.7 months with abiraterone or enzalutamide (HR=0.59, 95%CI 0.35–1.01; log-rank P=0.050).
  • Median time to Functional Assessment of Cancer Therapy-Prostate (FACT-P) score deterioration was 14.8 months with cabazitaxel versus 8.9 months with abiraterone or enzalutamide (HR=0.72, 95%CI 0.44‒1.20; log-rank P=0.21).
  • There was a significant treatment effect seen in changes from baseline in the EuroQoL-5 dimensions, with the 5-level scale (EQ-5D-5L) utility index score favouring cabazitaxel over abiraterone or enzalutamide (P=0.030), but no difference was found for the EQ-5D-5L visual analogue scale (P=0.060).

“Here we show that cabazitaxel significantly improves pain response and time to pain progression and reduces the risk of developing symptomatic skeletal events compared with abiraterone or enzalutamide, and is not associated with a detrimental effect on HRQOL in patients with metastatic castration-resistant prostate cancer who have received previous docetaxel and progressed on the alternative androgen signalling inhibitor within the previous year,” write the authors.

Commenting on the study Simon Grieveson, Head of Research Funding at Prostate Cancer UK, said, “Cabazitaxel is already being offered to this group of men in the UK, but these findings reinforce the importance of ensuring the best treatments are made available to these men that will give them valuable extra time with their loved ones whilst giving them the best quality of life possible.”

 

Illustration by Maddalena Carrai

Total
0
Shares
Share 0
Tweet 0
Share 0
Share 0
Share 0
Related Topics
  • prostate cancer
  • quality of life
  • therapy
Janet Fricker

Janet Fricker is a medical writer specialising in oncology and cardiology. After researching articles for Cancerworld she runs, swims, and eats porridge.

Previous Article
  • News

Combined therapies offer the key to drug-resistant cancer

  • 5 October 2020
  • Janet Fricker
View Post
Next Article
  • News

Cancer deaths fall, health disparities persist, cancer research affected, reports AACR

  • 6 October 2020
  • Janet Fricker
View Post
You May Also Like
View Post
  • News

Study highlights need to reanalyse genomics and genetics of metastatic tumours

  • Janet Fricker
  • 27 January 2023
View Post
  • News

Current cervical cancer screening paradigm fails older women

  • Janet Fricker
  • 26 January 2023
View Post
  • News

Call-to-arms for Europe to provide essential paediatric anti-cancer medicines

  • Janet Fricker
  • 9 January 2023
View Post
  • News

Exercise-stimulated myokine production can extend survival in advanced prostate cancer

  • Janet Fricker
  • 9 January 2023
View Post
  • News

Five San Antonio take-aways to improve care of breast cancer patients

  • Janet Fricker
  • 16 December 2022
View Post
  • News

Repurposed drug combination reduces risk of recurrence following surgery for colorectal cancer

  • Janet Fricker
  • 16 December 2022
View Post
  • News

Aerobic activity to outcompete metastasis 

  • Janet Fricker
  • 2 December 2022
View Post
  • News

Ending cancer inequalities: European summit showcases new tools to inform policy

  • Anna Wagstaff
  • 30 November 2022

Leave a Reply Cancel reply

Your email address will not be published. Required fields are marked *

search
or search in Cancerworld archive
Newsletter

Subscribe free to
Cancerworld!

We'll keep you informed of the latest features and news with a fortnightly email

Subscribe now
Latest News
  • Study highlights need to reanalyse genomics and genetics of metastatic tumours
    • 27 January 2023
  • Current cervical cancer screening paradigm fails older women
    • 26 January 2023
  • Call-to-arms for Europe to provide essential paediatric anti-cancer medicines
    • 9 January 2023
  • Exercise-stimulated myokine production can extend survival in advanced prostate cancer
    • 9 January 2023
  • Five San Antonio take-aways to improve care of breast cancer patients
    • 16 December 2022
Article
  • The cancer patients still struggling to access drugs in the wake of anti-corruption reforms
    • 27 January 2023
  • Immunotherapy: outcomes of ultra low-dose trial offer hope for better global access
    • 26 January 2023
  • Cervical cancer elimination efforts boosted by simpler ways to identify and treat pre-cancerous lesions
    • 12 January 2023
Latest printed issue
Social

Would you follow us ?

Contents
  • AI in Genomics and Reporting for Clinical Practice
    • 26 January 2023
  • Telemedicine in Cancer Care: Monitoring, Follow-Up,Tele-Rehabilitation, Palliative and Supportive Care
    • 23 January 2023
  • AI application in diagnosis
    • 11 January 2023
MENU
  • About the Magazine
    • Editorial Team
    • Leadership and Management
    • Events
    • Magazine
    • Archive
    • Contacts
  • Articles
    • Policy
    • Practice Points
    • Delivery of Care
    • Biology basic
    • Medicine
    • Featured
  • Contents
    • News
    • Editorials
    • Interviews to the Expert
    • In the Hot Seat
    • Profiles
    • Obituaries
    • Voices
    • Partnership
    • Supported contents
  • Media Corner
    • Journalist Cancer Guide
    • Cancer Journalism Award
    • Cancer Journalist Grant
Cancerworld Magazine
  • About the Magazine
  • Articles
  • Media Corner
  • Privacy Policy
  • Cookie Policy

Cancerworld is funded by SPCC Sharing Progress in Cancer Care | Via Vincenzo Vela 6, 6500 Bellinzona - Switzerland | info@spcc.net

Archivio Cancerworld

Input your search keywords and press Enter.