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Cancerworld Magazine > antibody drug conjugate

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antibody drug conjugate

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It’s no longer taboo to suggest that some metastatic breast cancers may be curable
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It’s no longer taboo to suggest that some metastatic breast cancers may be curable

  • Janet Fricker
  • 30 April 2025

It’s long been clear that, in most patients with metastatic HER-positive breast cancer, adding effective HER2 blockade to cytotoxics can result in very prolonged responses. Janet Fricker reports on the prospective trials building evidence on whether – and in whom…

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Antibody-drug conjugate proves effective against active brain metastases
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Antibody-drug conjugate proves effective against active brain metastases

  • Janet Fricker
  • 26 September 2024

The antibody drug conjugate trastuzumab deruxtecan (T-DXd) showed substantial intracranial activity in patients with HER2-positive breast cancer whose disease had metastasised to the brain. The DESTINY-Breast12 study, presented at the Congress of the European Society for Medical Oncology (ESMO), held…

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