Posts by tag
breast cancer
Bacterial decolonisation offers new strategy to prevent acute radiation dermatitis
Many cases of acute radiation dermatitis involve the common skin bacterium Staphylococcus aureus. Two linked papers in the same issue of JAMA Oncology, published online 4 May, suggest bacterial decolonisation of Staphylococcus aureus (S aureus) offers an effective approach for…
Slow decrease in breast density heightens breast cancer risk
Women with a slower decrease in breast density over time are at higher risk of developing breast cancer. The prospective cohort study, published in JAMA Oncology, online April 27, suggests that dynamic changes in breast density over time can be…
Prehabilitation programmes benefit breast cancer patients and save healthcare resources
Referring patients with early-stage breast cancer to exercise programmes prior to surgery not only improves health-related quality of life measures but also lowers overall healthcare costs. The study, abstract 1385675, was presented at the American Society of Breast Surgeons Annual…
Body weight influences breast cancer risk in women with BRCA1 and 2 mutations
Obesity may be a factor contributing to DNA damage in the breast tissue of women with BRCA1 or BRCA2 mutations. The study, published in Science Translational Medicine, February 22, suggests maintaining a healthy body weight or pharmacologically targeting oestrogen or…
Radiotherapy can be safely omitted in older women with low-risk breast cancer
Leaving out radiotherapy does not affect survival after breast-conserving surgery in older women with low-risk hormone-receptor-positive early breast cancer. Ten-year outcomes for the PRIME II trial, published in the New England Journal of Medicine, February 16, found that, although omission…
Cancer could overtake cardiovascular disease as leading cause of death in type 2 diabetes
Mortality from cancer has increased among older people with type 2 diabetes. The UK cohort study, published in Diabetologica, 24 January, found people with type 2 diabetes were at particular risk of mortality from colorectal, pancreatic, liver and endometrial cancers.…
Study highlights need to reanalyse genomics and genetics of metastatic tumours
Around one third of breast cancer patients showed molecular subtype shifts (especially involving luminal cancers) between their primary and metastatic tumours. The study, published in Nature Cancer, on December 30th, also revealed the presence of fewer immune cells in triple-negative…
Repurposed drug combination reduces risk of recurrence following surgery for colorectal cancer
Pharmacological suppression of adrenergic and inflammatory signalling using readily available drugs to lower blood pressure and reduce anxiety decreased the risk of post-surgical colorectal cancer (CRC) recurrence. The pilot COMPIT study, published in the European Journal of Surgical Oncology, 6…
Study defines subset of women benefitting from digital breast tomosynthesis
Digital breast tomosynthesis (DBT) offers an advantage over conventional digital mammography in only a tiny percentage of women, who have extremely dense breasts and a high risk of breast cancer. The cohort study, published in JAMA (June 14), found no…
Antibody-drug conjugates make their mark at ASCO
Reports of the results of two antibody-drug conjugates (ADCs), one for HER-low metastatic breast cancer, the other for metastatic lung cancer resistant to EGFR inhibitors, highlight the advances being made in this type of treatment. The DESTINY-Breast04 study, presented at…