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Cancer Immunotherapy
Artificial Sweetener Reduces Response to Immunotherapy
Could artificial sweeteners undo the benefits of immunotherapy? A study published in Cancer Discovery, July 30, found that melanoma and non-small cell lung cancer (NSCLC) patients who consume high levels of the artificial sweetener sucralose have worse responses to immunotherapy…
Microbiota-Derived Bile Acids as Androgen Receptor Antagonists Enhance Anti-Tumour Immunity
The gut microbiota can transform cholesterol-derived bile acids into metabolites capable of blocking androgen receptors and strengthening anti-cancer immunity. The study, published in Cell, April 15, demonstrates how one of the microbiota-derived secondary bile acids is capable of suppressing tumour…
Miriam Merad and the 2025 Sjöberg Prize: A Celebration of Innovation in Cancer Immunotherapy
Every year, the Sjöberg Prize, established by the Royal Swedish Academy of Sciences, honors researchers whose scientific discoveries in oncology are reshaping the understanding and treatment of cancer. The award stands alongside the most prestigious accolades in science, not only…
Ovarian cancer: mechanism conferring resistance to immunotherapy revealed
The presence of flagella, the propellers bacteria use to move, explains why immune checkpoint inhibitors do not work in patients with ovarian cancer. The study, published in Cancer Immunology Research, 11 February, suggests that immune cell recognition of bacterial flagella,…